Works are getting underway at Foyle Street Bus Centre from Monday, June 7.
This is part of a wider safety upgrade programme underway at more than 20 Translink stations across the network in coming months.
Translink say the works, which will take up to 14 weeks, will enhance passenger and staff safety with improved lighting, safety signage and installation of protective bollards.
Some resurfacing works will be required to bus departure areas which will require a temporary reduction of bus stands.
A Translink spokesperson: "These works will be undertaken in compliance with government and Public Health Agency recommendations on COVID-19.
"All efforts will be made to maintain appropriate social distancing for the worksite and ensure no restrictions on current social distancing measures at Foyle Street Bus Centre."
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